循环免疫复合物英文名称

发布网友发布时间：2024-10-02 20:51

共1个回答

热心网友时间：2024-10-19 07:27

Circulating immunocomplex, often abbreviated as CIC, refers to a type of medium-sized, soluble immune complexes that form in excess of antigens. These complexes are not cleared by phagocytic cells and cannot pass through the glomerular filtration barrier, allowing them to remain in the bloodstream and other bodily fluids. When vascular permeability increases, CIC can deposit in the walls of capillaries or adhere to the glomerular basement membrane, triggering an immune response known as immune complex deposition (ICD). The detection of CIC is valuable in diagnosing diseases, understanding their mechanisms, predicting outcomes, monitoring disease activity, and evaluating treatment efficacy.

The methods for detecting CIC are broadly categorized into antigen-specific and antigen-nonspecific approaches. Antigen-specific tests target specific antigens in the complexes, useful in diseases with known antigen-induced immune reactions. In contrast, antigen-nonspecific methods measure changes in immunoglobulin molecules upon antigen binding, regardless of the antigen's nature. However, these tests can be influenced by factors such as Ig class and subclass, complex size, antigen-to-antibody ratio, and补体 fixation ability, limiting their clinical utility.

Normal values for CIC in the blood are typically negative in tests like complement assays and coagulonephthrosis binding. Specific values can vary, with some studies reporting a threshold of 8.3 for positivity in PEG precipitation tests, and a limit of 28.4 mg/L in SPA sandwich ELISA trials. The presence of CIC in the serum is significant in various conditions, including systemic lupus erythematosus, rheumatoid arthritis, granulomatosis with polyangiitis, post-streptococcal glomerulonephritis, infectious diseases like hepatitis B, leprosy, dengue, and malaria, as well as in cancer patients, reflecting disease activity, treatment response, and potential etiology.