药物翻译

发布网友发布时间：2022-05-05 23:54

共2个回答

热心网友时间：2022-06-28 08:31

in efficacy to INH and PAS in reversal of infectiousness, cavity closure and prevention of INH resistance. This high dosage with PZA was, however, often associated with hepatitis. PZA was therefore mainly used as a second-line drug in the treatment of patients with drug-resistant strains. However, in the early 1970s, the first multi-centre study leading to the development of short-course regimens was carried out by the British Medical Research Council in East Africa.63 Mainly because of the earlier
功效异烟肼和PAS在传染性的逆转,腔关闭和预防异烟肼耐药性。然而,这种高剂量与PZA经常与肝炎有关。PZA因此主要用来作为二线药物治疗患者的耐药菌株。然而,在1970年代初,第一个多中心研究导致短期的发展方案是由英国医学研究理事会在东Africa.63主要是因为早期的
mouse studies on PZA at Cornell University and those on RMP in Paris, regimens with RMP, PZA (in a dose of 1.5–2.0 g daily) or thioacetazone (as a control) added to a basic regimen of streptomycin and INH, were given for 6 months. As judged by more frequent sputum conversion at 2 months and by the relapse rates after treatment, PZA was almost as effective as RMP as a sterilising drug. Subsequent clinical studies in Africa and other countries showed that the effects of RMP and PZA were synergistic.
老鼠研究PZA康奈尔大学和那些在巴黎,RMP方案与RMP PZA(每日剂量为1.5 - -2.0 g)或氨硫脲(控制)添加到链霉素、异烟肼的基本方案,给出了6个月。根据更频繁的痰转换在2个月和治疗后的复发率,PZA几乎RMP作为冲销药物一样有效。在非洲和其他国家后续临床研究表明,RMP和PZA协同的影响。
Synergism was shown as a rection in the proportion of positive 2-month cultures and, where appropriate,relapse rates in studies where PZA was added to an RMP-containing regimen64,65 and when RMP was added to a PZA-containing regimen. 66,67 These studies showed that treatment could be shortened
合作积极的比例减少了两个月的文化,并在适当情况下,复发率在研究PZA被添加到一个RMP-containing regimen64,65 RMP时添加到PZA-containing疗程。66、67这些研究表明,治疗可以缩短
from 12 months or more to 9 months if RMP or PZA were added to the regimen, but to 6 months if both were added.
从12个月以上9个月如果RMP或PZA被添加到方案,但如果都添加到6个月。

热心网友时间：2022-06-28 08:32

在疗效INH和PAS逆转传染性，空洞闭合INH resistance.This高剂量与PZA和预防的热量，但是，往往与肝炎有关。 PZA被因此主要作为二线药物的患者的耐药株的治疗。然而，在20世纪70年代初，第一个多中心研究导致短期课程方案的开发工作由英国医学研究理事会在东Africa.63因为PZA的earliermouse研究主要是在康奈尔大学和那些在贼法牧在巴黎，服法与贼法牧， PZA （在1.5-2.0克，每日剂量）或氨硫脲（作为对照）加入链霉素和异烟肼的基本方案，分别给予6个月。作为判断2个月时更频繁的痰菌阴转和治疗后的复发率， PZA几乎是一样有效的贼法牧的杀菌药物。在非洲和其他国家随后的临床研究表明， RMP和PZA的影响进行了synergistic.Synergism显示了作为在正极2个月的培养物，并在适当情况下，在PZA加入到一个RMP研究复发率的比例降低含regimen64 ， 65 ，当制冷剂管理加入到含PZA - regimen.66 ， 67这些研究表明，如果RMP或PZA加入到治疗方案可能是shortenedfrom 12个月或更多至9个月，但6个月，如果既增加了。