一溴甲烷的物质毒性
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发布时间：2022-04-24 02:44
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热心网友
时间：2023-10-22 18:03
编号 毒性类型 测试方法 测试对象 使用剂量 毒性作用 1 acute Inhalation Human - man 60000 ppm/2H 1.行为毒性Behavioral - convulsions or effect on seizure threshold 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - nausea or vomiting 2 acute Inhalation Human - child 1 gm/m3/2H 1.血液毒性Blood - change in clotting factors 3 acute Inhalation Human 35 ppm 1.行为毒性Behavioral - anorexia (human) 2.胃肠道毒性Gastrointestinal - nausea or vomiting 3.皮肤和附件毒性Skin and Appendages - corrosive (after topical exposure) 4 acute Administration onto the skin Human 35 gm/m3/40M-I 1.皮肤和附件毒性Skin and Appendages - dermatitis, irritative (after systemic exposure) 5 acute Oral Rodent - rat 214 mg/kg 1.Details of toxic effects not reported other than lethal dose value 6 acute Inhalation Rodent - rat 302 ppm/8H 1.行为毒性Behavioral - changes in motor activity (specific assay) 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.营养和代谢系统毒性Nutritional and Gross Metabolic - body temperature decrease 7 acute Subcutaneous Rodent - rat 135 mg/kg 1.Details of toxic effects not reported other than lethal dose value 8 acute Inhalation Rodent - mouse 1540 mg/m3/2H 1.Details of toxic effects not reported other than lethal dose value 9 acute Oral Mammal - dog 500 mg/kg 1.心脏毒性Cardiac - pulse rate increase, without fall in BP 2.胃肠道毒性Gastrointestinal - nausea or vomiting 3.营养和代谢系统毒性Nutritional and Gross Metabolic - body temperature decrease 10 acute Inhalation Rodent - rabbit 28900 mg/m3/30M 1.Details of toxic effects not reported other than lethal dose value 11 acute Inhalation Rodent - guinea pig 300 ppm/9H 1.行为毒性Behavioral - muscle weakness 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) 3.皮肤和附件毒性Skin and Appendages - hair 12 MutipleDose Oral Rodent - rat 21840 mg/kg/2Y-C 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes in urine composition 2.皮肤和附件毒性Skin and Appendages - hair 3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 13 MutipleDose Inhalation Rodent - rat 120 ppm/6H/13W-I 1.血液毒性Blood - pigmented or nucleated red blood cells 2.血液毒性Blood - changes in erythrocyte (RBC) count 3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 14 MutipleDose Inhalation Rodent - rat 150 ppm/6H/5D-I 1.生化毒性Biochemical - Enzyme inhibition, inction, or change in blood or tissue levels - other transferases 2.生化毒性Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) 15 MutipleDose Inhalation Rodent - rat 160 ppm/6H/6W-I 1.大脑毒性Brain and Coverings - other degenerative changes 2.嗅觉毒性Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified 3.心脏毒性Cardiac - other changes 16 MutipleDose Inhalation Rodent - rat 300 ppm/4H/3W-I 1.行为毒性Behavioral - somnolence (general depressed activity) 2.行为毒性Behavioral - ataxia 3.慢性病相关毒性Related to Chronic Data - death 17 MutipleDose Inhalation Rodent - mouse 200 ppm/6H/14D-I 1.慢性病相关毒性Related to Chronic Data - death 18 MutipleDose Inhalation Rodent - mouse 120 ppm/6H/13W-I 1.行为毒性Behavioral - muscle contraction or spasticity 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.慢性病相关毒性Related to Chronic Data - death 19 MutipleDose Inhalation Rodent - mouse 160 ppm/6H/6W-I 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) 2.内分泌毒性Endocrine - other changes 3.血液毒性Blood - changes in spleen 20 MutipleDose Inhalation Primate - monkey 250 mg/m3/8H/26W-I 1.周围神经毒性Peripheral Nerve and Sensation - spastic paralysis with or without sensory change 2.行为毒性Behavioral - convulsions or effect on seizure threshold 21 MutipleDose Inhalation Rodent - rabbit 130 mg/m3/8H/26W-I 1.周围神经毒性Peripheral Nerve and Sensation - spastic paralysis with or without sensory change 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) 3.慢性病相关毒性Related to Chronic Data - death 22 MutipleDose Inhalation Rodent - guinea pig 850 mg/m3/8H/26W-I 1.周围神经毒性Peripheral Nerve and Sensation - spastic paralysis with or without sensory change 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - chronic pulmonary edema 3.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 23 Mutation Bacteria - Salmonella typhimurium 400 ppm 24 Mutation Bacteria - Salmonella typhimurium 5 gm/m3 25 Mutation Bacteria - Salmonella typhimurium 3 pph 26 Mutation Bacteria - Klebsiella pneumoniae 4750 mg/m3 27 Mutation Inhalation Insect - Drosophila melanogaster 8 mg/L/1H (Continuous) 28 Mutation Inhalation Insect - Drosophila melanogaster 150 mg/m3/6H 29 Mutation Human Lymphocyte 95 mg/L 30 Mutation Human Lymphocyte 43000 ppm 31 Mutation Human Lymphocyte 5 mg/L 32 Mutation Inhalation Rodent - rat 338 ppm/6H/14D (Intermittent) 33 Mutation Inhalation Rodent - mouse 100 ppm/6H/14D (Intermittent) 34 Mutation Inhalation Rodent - mouse 200 ppm/6H/14D (Intermittent) 35 Mutation Rodent - mouse Lymphocyte 300 ug/L 36 Tumorigenic Oral Rodent - rat 3250 mg/kg/13W-I 1.致癌性Tumorigenic - Carcinogenic by RTECS criteria 2.胃肠道毒性Gastrointestinal - peritonitis 3.胃肠道毒性Gastrointestinal - tumors 37 Tumorigenic Inhalation Rodent - rat 30 ppm/6H/2.5Y-I 1.致癌性Tumorigenic - Carcinogenic by RTECS criteria 2.嗅觉毒性Sense Organs and Special Senses (Olfaction) - tumors 38 Reproctive Oral Rodent - rat 300 mg/kg,female 6-15 day(s) after conception 1.生殖毒性Reproctive - Maternal Effects - other effects 39 Reproctive Oral Rodent - rabbit 130 mg/kg,female 6-18 day(s) after conception 1.生殖毒性Reproctive - Maternal Effects - other effects
热心网友
时间：2023-10-22 18:03
编号 毒性类型 测试方法 测试对象 使用剂量 毒性作用 1 acute Inhalation Human - man 60000 ppm/2H 1.行为毒性Behavioral - convulsions or effect on seizure threshold 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - nausea or vomiting 2 acute Inhalation Human - child 1 gm/m3/2H 1.血液毒性Blood - change in clotting factors 3 acute Inhalation Human 35 ppm 1.行为毒性Behavioral - anorexia (human) 2.胃肠道毒性Gastrointestinal - nausea or vomiting 3.皮肤和附件毒性Skin and Appendages - corrosive (after topical exposure) 4 acute Administration onto the skin Human 35 gm/m3/40M-I 1.皮肤和附件毒性Skin and Appendages - dermatitis, irritative (after systemic exposure) 5 acute Oral Rodent - rat 214 mg/kg 1.Details of toxic effects not reported other than lethal dose value 6 acute Inhalation Rodent - rat 302 ppm/8H 1.行为毒性Behavioral - changes in motor activity (specific assay) 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.营养和代谢系统毒性Nutritional and Gross Metabolic - body temperature decrease 7 acute Subcutaneous Rodent - rat 135 mg/kg 1.Details of toxic effects not reported other than lethal dose value 8 acute Inhalation Rodent - mouse 1540 mg/m3/2H 1.Details of toxic effects not reported other than lethal dose value 9 acute Oral Mammal - dog 500 mg/kg 1.心脏毒性Cardiac - pulse rate increase, without fall in BP 2.胃肠道毒性Gastrointestinal - nausea or vomiting 3.营养和代谢系统毒性Nutritional and Gross Metabolic - body temperature decrease 10 acute Inhalation Rodent - rabbit 28900 mg/m3/30M 1.Details of toxic effects not reported other than lethal dose value 11 acute Inhalation Rodent - guinea pig 300 ppm/9H 1.行为毒性Behavioral - muscle weakness 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) 3.皮肤和附件毒性Skin and Appendages - hair 12 MutipleDose Oral Rodent - rat 21840 mg/kg/2Y-C 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes in urine composition 2.皮肤和附件毒性Skin and Appendages - hair 3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 13 MutipleDose Inhalation Rodent - rat 120 ppm/6H/13W-I 1.血液毒性Blood - pigmented or nucleated red blood cells 2.血液毒性Blood - changes in erythrocyte (RBC) count 3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 14 MutipleDose Inhalation Rodent - rat 150 ppm/6H/5D-I 1.生化毒性Biochemical - Enzyme inhibition, inction, or change in blood or tissue levels - other transferases 2.生化毒性Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) 15 MutipleDose Inhalation Rodent - rat 160 ppm/6H/6W-I 1.大脑毒性Brain and Coverings - other degenerative changes 2.嗅觉毒性Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified 3.心脏毒性Cardiac - other changes 16 MutipleDose Inhalation Rodent - rat 300 ppm/4H/3W-I 1.行为毒性Behavioral - somnolence (general depressed activity) 2.行为毒性Behavioral - ataxia 3.慢性病相关毒性Related to Chronic Data - death 17 MutipleDose Inhalation Rodent - mouse 200 ppm/6H/14D-I 1.慢性病相关毒性Related to Chronic Data - death 18 MutipleDose Inhalation Rodent - mouse 120 ppm/6H/13W-I 1.行为毒性Behavioral - muscle contraction or spasticity 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.慢性病相关毒性Related to Chronic Data - death 19 MutipleDose Inhalation Rodent - mouse 160 ppm/6H/6W-I 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) 2.内分泌毒性Endocrine - other changes 3.血液毒性Blood - changes in spleen 20 MutipleDose Inhalation Primate - monkey 250 mg/m3/8H/26W-I 1.周围神经毒性Peripheral Nerve and Sensation - spastic paralysis with or without sensory change 2.行为毒性Behavioral - convulsions or effect on seizure threshold 21 MutipleDose Inhalation Rodent - rabbit 130 mg/m3/8H/26W-I 1.周围神经毒性Peripheral Nerve and Sensation - spastic paralysis with or without sensory change 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) 3.慢性病相关毒性Related to Chronic Data - death 22 MutipleDose Inhalation Rodent - guinea pig 850 mg/m3/8H/26W-I 1.周围神经毒性Peripheral Nerve and Sensation - spastic paralysis with or without sensory change 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - chronic pulmonary edema 3.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 23 Mutation Bacteria - Salmonella typhimurium 400 ppm 24 Mutation Bacteria - Salmonella typhimurium 5 gm/m3 25 Mutation Bacteria - Salmonella typhimurium 3 pph 26 Mutation Bacteria - Klebsiella pneumoniae 4750 mg/m3 27 Mutation Inhalation Insect - Drosophila melanogaster 8 mg/L/1H (Continuous) 28 Mutation Inhalation Insect - Drosophila melanogaster 150 mg/m3/6H 29 Mutation Human Lymphocyte 95 mg/L 30 Mutation Human Lymphocyte 43000 ppm 31 Mutation Human Lymphocyte 5 mg/L 32 Mutation Inhalation Rodent - rat 338 ppm/6H/14D (Intermittent) 33 Mutation Inhalation Rodent - mouse 100 ppm/6H/14D (Intermittent) 34 Mutation Inhalation Rodent - mouse 200 ppm/6H/14D (Intermittent) 35 Mutation Rodent - mouse Lymphocyte 300 ug/L 36 Tumorigenic Oral Rodent - rat 3250 mg/kg/13W-I 1.致癌性Tumorigenic - Carcinogenic by RTECS criteria 2.胃肠道毒性Gastrointestinal - peritonitis 3.胃肠道毒性Gastrointestinal - tumors 37 Tumorigenic Inhalation Rodent - rat 30 ppm/6H/2.5Y-I 1.致癌性Tumorigenic - Carcinogenic by RTECS criteria 2.嗅觉毒性Sense Organs and Special Senses (Olfaction) - tumors 38 Reproctive Oral Rodent - rat 300 mg/kg,female 6-15 day(s) after conception 1.生殖毒性Reproctive - Maternal Effects - other effects 39 Reproctive Oral Rodent - rabbit 130 mg/kg,female 6-18 day(s) after conception 1.生殖毒性Reproctive - Maternal Effects - other effects
热心网友
时间：2023-10-22 18:03
编号 毒性类型 测试方法 测试对象 使用剂量 毒性作用 1 acute Inhalation Human - man 60000 ppm/2H 1.行为毒性Behavioral - convulsions or effect on seizure threshold 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - respiratory stimulation 3.胃肠道毒性Gastrointestinal - nausea or vomiting 2 acute Inhalation Human - child 1 gm/m3/2H 1.血液毒性Blood - change in clotting factors 3 acute Inhalation Human 35 ppm 1.行为毒性Behavioral - anorexia (human) 2.胃肠道毒性Gastrointestinal - nausea or vomiting 3.皮肤和附件毒性Skin and Appendages - corrosive (after topical exposure) 4 acute Administration onto the skin Human 35 gm/m3/40M-I 1.皮肤和附件毒性Skin and Appendages - dermatitis, irritative (after systemic exposure) 5 acute Oral Rodent - rat 214 mg/kg 1.Details of toxic effects not reported other than lethal dose value 6 acute Inhalation Rodent - rat 302 ppm/8H 1.行为毒性Behavioral - changes in motor activity (specific assay) 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.营养和代谢系统毒性Nutritional and Gross Metabolic - body temperature decrease 7 acute Subcutaneous Rodent - rat 135 mg/kg 1.Details of toxic effects not reported other than lethal dose value 8 acute Inhalation Rodent - mouse 1540 mg/m3/2H 1.Details of toxic effects not reported other than lethal dose value 9 acute Oral Mammal - dog 500 mg/kg 1.心脏毒性Cardiac - pulse rate increase, without fall in BP 2.胃肠道毒性Gastrointestinal - nausea or vomiting 3.营养和代谢系统毒性Nutritional and Gross Metabolic - body temperature decrease 10 acute Inhalation Rodent - rabbit 28900 mg/m3/30M 1.Details of toxic effects not reported other than lethal dose value 11 acute Inhalation Rodent - guinea pig 300 ppm/9H 1.行为毒性Behavioral - muscle weakness 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) 3.皮肤和附件毒性Skin and Appendages - hair 12 MutipleDose Oral Rodent - rat 21840 mg/kg/2Y-C 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - other changes in urine composition 2.皮肤和附件毒性Skin and Appendages - hair 3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 13 MutipleDose Inhalation Rodent - rat 120 ppm/6H/13W-I 1.血液毒性Blood - pigmented or nucleated red blood cells 2.血液毒性Blood - changes in erythrocyte (RBC) count 3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 14 MutipleDose Inhalation Rodent - rat 150 ppm/6H/5D-I 1.生化毒性Biochemical - Enzyme inhibition, inction, or change in blood or tissue levels - other transferases 2.生化毒性Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) 15 MutipleDose Inhalation Rodent - rat 160 ppm/6H/6W-I 1.大脑毒性Brain and Coverings - other degenerative changes 2.嗅觉毒性Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified 3.心脏毒性Cardiac - other changes 16 MutipleDose Inhalation Rodent - rat 300 ppm/4H/3W-I 1.行为毒性Behavioral - somnolence (general depressed activity) 2.行为毒性Behavioral - ataxia 3.慢性病相关毒性Related to Chronic Data - death 17 MutipleDose Inhalation Rodent - mouse 200 ppm/6H/14D-I 1.慢性病相关毒性Related to Chronic Data - death 18 MutipleDose Inhalation Rodent - mouse 120 ppm/6H/13W-I 1.行为毒性Behavioral - muscle contraction or spasticity 2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 3.慢性病相关毒性Related to Chronic Data - death 19 MutipleDose Inhalation Rodent - mouse 160 ppm/6H/6W-I 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) 2.内分泌毒性Endocrine - other changes 3.血液毒性Blood - changes in spleen 20 MutipleDose Inhalation Primate - monkey 250 mg/m3/8H/26W-I 1.周围神经毒性Peripheral Nerve and Sensation - spastic paralysis with or without sensory change 2.行为毒性Behavioral - convulsions or effect on seizure threshold 21 MutipleDose Inhalation Rodent - rabbit 130 mg/m3/8H/26W-I 1.周围神经毒性Peripheral Nerve and Sensation - spastic paralysis with or without sensory change 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) 3.慢性病相关毒性Related to Chronic Data - death 22 MutipleDose Inhalation Rodent - guinea pig 850 mg/m3/8H/26W-I 1.周围神经毒性Peripheral Nerve and Sensation - spastic paralysis with or without sensory change 2.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - chronic pulmonary edema 3.肺部、*或者呼吸毒性Lungs, Thorax, or Respiration - dyspnea 23 Mutation Bacteria - Salmonella typhimurium 400 ppm 24 Mutation Bacteria - Salmonella typhimurium 5 gm/m3 25 Mutation Bacteria - Salmonella typhimurium 3 pph 26 Mutation Bacteria - Klebsiella pneumoniae 4750 mg/m3 27 Mutation Inhalation Insect - Drosophila melanogaster 8 mg/L/1H (Continuous) 28 Mutation Inhalation Insect - Drosophila melanogaster 150 mg/m3/6H 29 Mutation Human Lymphocyte 95 mg/L 30 Mutation Human Lymphocyte 43000 ppm 31 Mutation Human Lymphocyte 5 mg/L 32 Mutation Inhalation Rodent - rat 338 ppm/6H/14D (Intermittent) 33 Mutation Inhalation Rodent - mouse 100 ppm/6H/14D (Intermittent) 34 Mutation Inhalation Rodent - mouse 200 ppm/6H/14D (Intermittent) 35 Mutation Rodent - mouse Lymphocyte 300 ug/L 36 Tumorigenic Oral Rodent - rat 3250 mg/kg/13W-I 1.致癌性Tumorigenic - Carcinogenic by RTECS criteria 2.胃肠道毒性Gastrointestinal - peritonitis 3.胃肠道毒性Gastrointestinal - tumors 37 Tumorigenic Inhalation Rodent - rat 30 ppm/6H/2.5Y-I 1.致癌性Tumorigenic - Carcinogenic by RTECS criteria 2.嗅觉毒性Sense Organs and Special Senses (Olfaction) - tumors 38 Reproctive Oral Rodent - rat 300 mg/kg,female 6-15 day(s) after conception 1.生殖毒性Reproctive - Maternal Effects - other effects 39 Reproctive Oral Rodent - rabbit 130 mg/kg,female 6-18 day(s) after conception 1.生殖毒性Reproctive - Maternal Effects - other effects
