surrogate marker是什么意思

发布网友发布时间：2022-08-26 08:16

共2个回答

热心网友时间：2023-12-15 02:54

Surrogate markers是指药品审批中某特别的可以用来替代作为临床靶点的临床测量的生物标志物. 比如胆固醇水平的测量可以作为动脉粥样硬化的surrogate marker..... 当前发明中采用amyloid imaging作为抗淀粉样蛋白治疗功效的surrogate marker.
Surrogate markers are a special type of biomarker that may be used in place of clinical measurements as a clinical endpoint for drug approval purposes. Thus, the methods described herein are useful in drug development trials. For example, the measurement of cholesterol levels is now an accepted surrogate marker of atherosclerosis. In addition, the methods are clinically useful in assisting patient management decisions. In that regard, quantitative evaluations of amyloid burden can improve clinical decisions concerning drug dose or treatment selections. The present invention involves the use of amyloid imaging as a surrogate marker of efficacy for anti-amyloid therapies.

热心网友时间：2023-12-15 02:54

surrogate marker
替代指标
代理标记