哪位大侠能提供这篇俄罗斯专利的全文啊?>RU2008144179A,谢谢啦

发布网友 发布时间：2022-05-12 16:44

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热心网友 时间：2023-10-14 03:33

Invention relates down the field of biotechnology, medical chemistry, microbiology and can be used before the pharmaceutical instry for obtaining the biologically active steroid compounds, which contain 11β-[gidroksigruppu], which answers at the point of the presence in molecule of antipyretic activity.

The 11β- hydroxylation of steroids is considered as as far as one of the most significant reactions before a number of steroid biotransformations, t [k] it serves for obtaining the glucocorticoids of antipyretic and antiallergic action, such as hydrocortisone, prednisolone, and also the flouridated corticosteroids (triamcinolone, dexamethasone, etc) on an instrial scale [1].

A maximum quantity of methods the 11β- hydroxylations of Δ4-3- steroids are the methods of obtaining the hydrocortisone ([S]21[O]5[N]30, hydrocortisone, Kendall's substance “F”, [pregn]-4- ene -11β, 17α, 21-triol-3,20- dione) - the representative of the important class of the medicines of steroid nature [2-25]. As the independent preparation/hydrocortisone is used for treating arthritis, bursitis, inflammatory and allergic diseases of the skin and others it also it serves as the initial substratum before the synthesis of other corticoids - cortisone, prednisolone, prednisone, [metilprednizolona] [2]. Another 11β- hydroxylation is necessary for obtaining dexamethasone according to the diagram through 16α-[metilkorteksolon].

They present also interest as connections for the sake of the high physiological activity and another 11β-[gidroksiproizvodnye] Δ4-3-[ketosteroidov] [22-28]. 11β-[Gidroksisteroidy] are obtained as far as the introction of 11- hydroxyl group beside the steroid molecule with the aid of the microorganisms - the lowest fungi. However, in contrast to the 11α- hydroxylation, which is achieved more than 300 forms of microorganisms, capability for the accumulation of 11β-[gidroksisteroidov] with the satisfactory output, but before the mixture for the sake of 11α-[gidroksiproktami], it is inherent before the limited number of forms of fungi - Absidia of orchidis, Cunninghamella of blakesleeana, C.elegans, Cochliobolus of lunatus [2, 6, 13, 16, 20, 28]. And only strains Of curvularia of lunata (collections - [ATSS], IFO, NRRL, BKM and other) of 35 known forms of the mold fungus of the kind Of curvularia widespread before nature conct the hydroxylation Of δ4-3-[ketosteroidov] predominantly down the 11β- position and they serve after biocatalyst for obtaining the hydrocortisone [2-27]. The merit of the form Of [s].lunata is also capability for the 11β- hydroxylation of both 21-[gidroksisteroidov] and 21-[metilsoderzhashchikh] steroids [2, 3, 27].
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热心网友 时间：2023-10-14 03:34

只能找到第一页的文件。。。。将就着看吧，不指望采纳答案咯。。

热心网友 时间：2023-10-14 03:34

直接到佰腾网 直接查看 就可以了 查看专利！